Prof. dr hab. Jolanta Jura Prof. dr hab. Jolanta Jura

Address:

 

Department of General Biochemistry

Faculty of Biochemistry, Biophysics and Biotechnology

Jagiellonian University

ul. Gronostajowa 7

30-387 Kraków

 

Room: B125

Phone: 12 664 63 59

E–mail: jolanta.jura@uj.edu.pl

 

Education and Titles:

 

2014 – Professor, (molecular biology), Jagiellonian University, Krakow

2000 – DSc in Biology (habilitation; human genetics), A. Mickiewicz University, Poznan

1994 - Ph.D. in Biology (human genetics), Marcinkowski Medical Academy, Poznan

1990 - MSc in Biology (human genetics), M. Copernicus University, Torun

 

Positions:

 

1990 - 2000 - Institute of Human Genetics, Polish Academy of Sciences, Poznan; position: assistant, senior assistant

2000 - 2010 -  Department of Cellular Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow; position: adjunct

2010 - 2014 - Department of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow; position: associate professor

since 2014 - Department of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow; position: professor

2014 - 2020 - Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow; position: Vice-dean for Research and Intenational Relations of the BBB Faculty

since 2020 - Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow; position: Dean of the BBB Faculty

 

Honors and awards:

 

2022 - First Award of the Rector of Jagiellonian University for scientific achievements (team award)

2010 - First Award of the Rector of Jagiellonian University for scientific achievements (team award)

2009 - Servier Award and Polish Society of Diabetology - "Hope giving discoveries"  for the best project

2000 - J. Sniadecki's Award for scientific achievements: "Characteristic and  identification of mutations in human genes: TSC1, XPMC2, RalGDS, DMD, RYR1 and APC" (team award).

1999 – Scientific Committee City of Poznan award  for scientific achievements: „Molecular background of human and animal genetic diseases" (team award).

1996 – Fellowship of Fundation for Polish Science – one year fellowship at Brigham and Women's Hospital, Harvard Medical School, in Boston

 

Internships and work abroad:

 

2010 - Marie Curie Host Fellowships for the Transfer of Knowledge, FP6 project; Laboratory of Oncology, G. Gaslini Institute, Genova, Italy; 2 months

2007 - Marie Curie Host Fellowships for the Transfer of Knowledge, FP6 project, Institute of Biomedical and Biological Sciences, Glasgow University; 2 months.

1996 – 1998 - Brigham and Women's Hospital, Harvard Medical School, Boston, USA – 2 years

1995 - Human Genetic Institute, Bonn, Germany; 2 weeks

1991 - Human Genetic Institute, Getingen, Germany; 3 months

 

Professional Societies:

 

Polish Society for Biochemistry, member of the Presidium of the Management Board

European Society for Dermatological Research, member

Polish Society of Human Genetics, member

Federation of European Biochemical Societies, member of the international committee for the evaluation of scholarship applications

 

Subject of interest:

  • regulation of inflammatory processes
  • signals regulating NFkappaB activity
  • MCPIP1 – Rnase regulating mRNA stability - its role in diseases with inflammatory background
  • inflammatory processes and carcinogenesis
  • skin homeostasis and pathological processes of this organ

 

Most significant publications:

 

1. Kwiatkowska J, Slomski R, Jozwiak S, Short MP, Kwiatkowski DJ. Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1. Genomics. 1997 Sep 15;44(3):350-4. PubMed PMID: 9325058.

 

2. van Slegtenhorst M, de Hoogt R, Hermans C, Nellist M, Janssen B, Verhoef S, Lindhout D, van den Ouweland A, Halley D, Young J, Burley M, Jeremiah S, Woodward K, Nahmias J, Fox M, Ekong R, Osborne J, Wolfe J, Povey S, Snell RG, Cheadle JP,  Jones AC, Tachataki M, Ravine D, Sampson JR, Reeve MP, Richardson P, Wilmer F, Munro C, Hawkins TL, Sepp T, Ali JB, Ward S, Green AJ, Yates JR, Kwiatkowska J, Henske EP, Short MP, Haines JH, Jozwiak S, Kwiatkowski DJ. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science. 1997 Aug 8;277(5327):805-8. PubMed PMID: 9242607

 

3. Humphrey D, Kwiatkowska J, Henske EP, Haines JL, Halley D, van Slegtenhorst M, Kwiatkowski DJ. Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1. Ann Hum Genet. 1997 Jul;61(Pt 4):299-305. PubMed PMID: 9365783

 

4. Kwiatkowska J, Jozwiak S, Hall F, Henske EP, Haines JL, McNamara P, Braiser J,Wigowska-Sowinska J, Kasprzyk-Obara J, Short MP, Kwiatkowski DJ. Comprehensivemutational analysis of the TSC1 gene: observations on frequency of mutation, associated features, and nonpenetrance. Ann Hum Genet. 1998 Jul;62(Pt 4):277-85. PubMed PMID: 9924605

 

5. Kwiatkowska J, Wigowska-Sowinska J, Napierala D, Slomski R, Kwiatkowski DJ. Mosaicism in tuberous sclerosis as a potential cause of the failure of molecular diagnosis. N Engl J Med. 1999 Mar 4;340(9):703-7. PubMed PMID: 10053179

 

6. Mizgalska D, Wegrzyn P, Murzyn K, Kasza A, Koj A, Jura J, Jarzab B, Jura J. Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA. FEBS J. 2009 Dec;276(24):7386-99. PubMed PMID: 19909337

 

7. Skalniak L, Mizgalska D, Zarebski A, Wyrzykowska P, Koj A, Jura J. Regulatory feedback loop between NF-kappaB and MCP-1-induced protein 1 RNase. FEBS J. 2009 Oct;276(20):5892-905. PubMed PMID: 19747262

 

Publications from last 5 years:

 

1.  Szukala W, Lichawska-Cieslar A, Krajewski PK, Kulecka M, Rumienczyk I, Mikula M, Matusiak Ł, Jura J, Szepietowski JC. An Atlas of the Hidradenitis Suppurativa Transcriptome. Dermatol Ther (Heidelb). 2024. Pubmed PMID: 38183615

2.  Lichawska-Cieslar A, Szukala W, Prajsnar TK, Pooranachandran N, Kulecka M, Dabrowska M, Mikula M, Rakus K, Chadzinska M, Jura J. MCPIP1 functions as a safeguard of early embryonic development. Sci Rep. 2023; 13(1):16944. PubMed PMID: 37805647

3. Mucha O, Skupien-Rabian B, Slota A, Trzos K, Pydyn N, Podlewski B, Jura J, Kotlinowski J. Hepatic Mcpip1 regulates adaptation to food restriction in mice. Acta Biochim Pol. 2023; 70(4):919-925. PubMed PMID: 37929720

4. Pydyn N, Kadluczka J, Major P, Hutsch T, Belamri K, Malczak P, Radkowiak D, Budzynski A, Miekus K, Jura J, Kotlinowski J. Hepatic MCPIP1 protein levels are reduced in NAFLD patients and are predominantly expressed in cholangiocytes and liver endothelium. Hepatol Commun. 2023; 7(3):e0008. PubMed PMID: 36809310

5. Szukala W, Rumienczyk I, Mikula M, Goryca K, Eckhart L, Koziel J, Jura J, Lichawska-Cieslar A. MCPIP1 controls effects of myeloid cells on skin carcinogenesis and hair growth. J Invest Dermatol. 2023; 26:S0022-202X(23)03192-5. PMID: PubMed 38154560

 

6. Szukala W, Pilarczyk-Zurek M, Folkert J, Kotlinowski J, Koziel J, Jura J. Depletion of Mcpip1 in murine myeloid cells results in intestinal dysbiosis followed by allergic inflammation. Biochim Biophys Acta Mol Basis Dis. 2023; 1869(7):166764. PubMed PMID: 37257731

7. Pydyn N, Kadluczka J, Major P, Hutsch T, Belamri K, Malczak P, Radkowiak D, Budzynski A, Miekus K, Jura J, Kotlinowski J. Hepatic MCPIP1 protein levels are reduced in NAFLD patients and are predominantly expressed in cholangiocytes and liver endothelium. Hepatol Commun. 2023 Feb 20;7(3):e0008. PubMed PMID: 36809310

 

8. Marona P, Górka J, Kwapisz O, Jura J, Rys J, Hoffman RM, Miekus K. Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation. Cell Death Dis. 2022 Sep 22;13(9):814. PubMed PMID: 36138026

 

9. Gorka J, Marona P, Kwapisz O, Rys J, Jura J, Miekus K. MCPIP1 regulates focal adhesion kinase and Rho GTPase-dependent migration in clear cell renal cell carcinoma. Eur J Pharmacol. 2022 May 5;922:174804. PubMed PMID: 35257717

 

10. Trzos K, Pydyn N, Jura J, Kotlinowski J.. Selected transgenic murine models of human autoimmune liver diseases. Pharmacol Rep. 2022 Apr;74(2):263-272. PubMed PMID: 35032321

 

11. Szukala W, Lichawska-Cieslar A, Pietrzycka R, Kulecka M, Rumienczyk I, Mikula M, Chlebicka I, Konieczny P, Dziedzic K, Szepietowski JC, Fontemaggi G, Rys J, Jura J. Loss of epidermal MCPIP1 is associated with aggressive squamous cell carcinoma. J Exp Clin Cancer Res. 2021 Dec 13;40(1):391. PubMed PMID: 34903245

 

12. Gorka J, Marona P, Kwapisz O, Waligórska A, Pospiech E, Dobrucki JW, Rys J, Jura J, Miekus K. MCPIP1 inhibits Wnt/β-catenin signaling pathway activity and modulates epithelial-mesenchymal transition during clear cell renal cell carcinoma progression by targeting miRNAs. Oncogene. 2021 Dec;40(50):6720-6735. PubMed PMID: 34657130

 

13. Krajewski PK, Szukała W, Lichawska-Cieślar A, Matusiak Ł, Jura J, Szepietowski JC. MCPIP1/Regnase-1 Expression in Keratinocytes of Patients with Hidradenitis Suppurativa: Preliminary Results. Int J Mol Sci. 2021 Jul 6;22(14):7241. PubMed PMID: 34298861

 

14. Gasiorek A, Dobosz E, Potempa B, Ciaston I, Wilamowski M, Oruba Z, Lamont RJ, Jura J, Potempa J, Koziel J. Subversion of Lipopolysaccharide Signaling in Gingival Keratinocytes via MCPIP-1 Degradation as a Novel Pathogenic Strategy of Inflammophilic Pathobionts. mBio. 2021 Jun 29;12(3):e0050221. PubMed PMID: 34182783

 

15. Pydyn N, Żurawek D, Kozieł J, Kus E, Wojnar-Lason K, Jasztal A, Fu M, Jura J, Kotlinowski J. Role of Mcpip1 in obesity-induced hepatic steatosis as determined by myeloid and liver-specific conditional knockouts. FEBS J. 2021 Nov;288(22):6563-6580. PubMed PMID: 34058074

 

16. Dobosz E, Wadowska M, Kaminska M, Wilamowski M, Honarpisheh M, Bryzek D, Potempa J, Jura J, Lech M, Koziel J. MCPIP-1 Restricts Inflammation via Promoting Apoptosis of Neutrophils. Front Immunol. 2021 Feb 26;12:627922. PubMed PMID: 33717148

 

17. Kwapisz O, Górka J, Korlatowicz A, Kotlinowski J, Waligórska A, Marona P, Pydyn N, Dobrucki JW, Jura J, Miekus K. Fatty Acids and a High-Fat Diet Induce Epithelial-Mesenchymal Transition by Activating TGFβ and β-Catenin in Liver Cells. Int J Mol Sci. 2021 Jan 28;22(3):1272. PubMed PMID: 33525359

 

18. Kotlinowski J, Hutsch T, Czyzynska-Cichon I, Wadowska M, Pydyn N, Jasztal A, Kij A, Dobosz E, Lech M, Miekus K, Pośpiech E, Fu M, Jura J, Koziel J, Chlopicki S. Deletion of Mcpip1 in Mcpip1fl/flAlbCre mice recapitulates the phenotype of human primary biliary cholangitis. Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166086. PubMed PMID: 33513427

 

19. Lichawska-Cieslar A, Konieczny P, Szukala W, Declercq W, Fu M, Jura J. Loss of keratinocyte Mcpip1 abruptly activates the IL-23/Th17 and Stat3 pathways in skin inflammation. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118866. PubMed PMID: 33007332

 

20. Musson R, Szukała W, Jura J. MCPIP1 RNase and Its Multifaceted Role. Int J Mol Sci. 2020 Sep 29;21(19):7183. PubMed PMID: 33003343

 

21. Gorka J, Marona P, Kwapisz O, Rys J, Jura J, Miekus K. The anti-inflammatory protein MCPIP1 inhibits the development of ccRCC by maintaining high levels of tumour suppressors. Eur J Pharmacol. 2020 Dec 5;888:173591. PubMed PMID: 32971087

 

22. Pajdzik K, Wilamowski M, Żurawek D, Stopa KB, Nodzyński M, Kalita A, Jura J. Anterior gradient 2 promotes tumorigenesis through upregulation of CCAAT-enhancer binding protein beta and hypoxia-inducible factor-2α and subsequent secretion of interleukin-6, interleukin-8, and vascular endothelial growth factor in the Caki-1 clear cell renal cell carcinoma cell line. IUBMB Life. 2020 Aug;72(8):1807-1818. PubMed PMID: 32593213

 

23. Pydyn N, Miękus K, Jura J, Kotlinowski J.. New therapeutic strategies in nonalcoholic fatty liver disease: a focus on promising drugs for nonalcoholic steatohepatitis. Pharmacol Rep. 2020 Feb;72(1):1-12. PubMed PMID: 32016853

 

24. Losko M, Dolicka D, Pydyn N, Jankowska U, Kedracka-Krok S, Kulecka M, Paziewska A, Mikula M, Major P, Winiarski M, Budzynski A, Jura J. Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism. Cell Mol Life Sci. 2020 Dec;77(23):4899-4919. PubMed PMID: 31893310

 

25. Konieczny P, Lichawska-Cieslar A, Kwiecinska P, Cichy J, Pietrzycka R, Szukala W, Declercq W, Devos M, Paziewska A, Rumienczyk I, Kulecka M, Mikula M, Fu M, Borowczyk J, Santamaria-Babí LF, Jura J. Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation. J Mol Med (Berl). 2019 Dec;97(12):1669-1684. PubMed PMID: 31786670

 

26. Miekus K, Kotlinowski J, Lichawska-Cieslar A, Rys J, Jura J. Activity of MCPIP1 RNase in tumor associated processes. J Exp Clin Cancer Res. 2019 Oct 21;38(1):421. PubMed PMID: 31639017

 

27. Pydyn N, Kadluczka J, Kus E, Pospiech E, Losko M, Fu M, Jura J, Kotlinowski J. RNase MCPIP1 regulates hepatic peroxisome proliferator-activated receptor gamma via TXNIP/PGC-1alpha pathway. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1458-1471. PubMed PMID: 31185306

 

28. Wawro M, Wawro K, Kochan J, Solecka A, Sowinska W, Lichawska-Cieslar A, Jura J, Kasza A. ZC3H12B/MCPIP2, a new active member of the ZC3H12 family. RNA. 2019 Jul;25(7):840-856. PubMed PMID: 30988100

 

29. Kotlinowski J, Bukowska-Strakova K, Koppolu A, Kosińska J, Pydyn N, Stawinski P, Wilamowski M, Nowak W, Józkowicz A, Baran J, Płoski R, Jura J. A Novel Monoallelic Nonsense Mutation in the NFKB2 Gene Does Not Cause a Clinical Manifestation. Front. Genet. 2019; 10, 140. PubMed PMID: 30863427

 

30. Marona P, Górka J, Kotlinowski J, Majka M, Jura J, Miekus K. C-Met as a Key Factor Responsible for Sustaining Undifferentiated Phenotype and Therapy Resistance in Renal Carcinomas. Cells 2019; 8, 272. PubMed PMID: 30909397