Address:

Department of General Biochemistry

Faculty of Biochemistry, Biophysics and Biotechnology

Jagiellonian University

ul. Gronostajowa 7

30-387 Kraków

Room: C144

Phone: 12 664 61 39

E–mail: j.kotlinowski@uj.edu.pl

Education and Titles:

2012 - PhD in biochemistry. Thesis title: "Effect of PPARgamma activators on proangiogenic progenitor cells functions in diabetic mice". Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland.

2006 – MSc in biotechnology. Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland.

Positions:

Since 10.2013 – Department of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland

04.2012 – 10.2013 – Post-doctoral training in the "Inflammation" research group led by Miguel Soares. Instituto Gulbenkian de Ciência, Oeiras, Portugal

2006 – 2012 – PhD program, Faculty of Biochemistry, Biophysics and Biotechnology Jagiellonian University, Cracow, Poland

Honors and awards:

2014 - A PhD diploma in biochemistry awarded with distinction by the Council of Biochemistry, Biophysics and Biotechnology Faculty at Jagiellonian University, Cracow, Poland. 

2011 - Award from Rector of Jagiellonian University for researchers from the Department of Medical Biotechnology (award for the team), prize for the outstanding scientific publications.

2011 - Award for the popular science article in Polish. J. Kotlinowski. Jak poprawić funkcjonowanie naczyń krwionośnych w cukrzycy? [Improving blood vessels function in diabetes.] Forum Akademickie 05/2011.

2009 - Stipend from the Cracow Town Council for the best PhD students in the academic year 2009/2010.

Conference Stipends: VIII Parnas Conference, Warsaw, Poland, 27-31.08.2011 and 34th FEBS Congress, Prague, Czech Republic, 4-9.07.2009.

2006 - Scholarship for the best 1st year PhD students from Malopolskie Voivodeship, Sapere Auso.

Internships and work abroad:

04.2012-10.2013 – Post-doctoral training in the "Inflammation" research group led by Miguel Soares, Instituto Gulbenkian de Ciência, Oeiras, Portugal.

02.2005 - 08.2005 – Socrates – Erasmus scholarship. Department of Gynecology and Obstetrics, Lunds University, Lund, Sweden.

Courses and trainings:

9-10.12.2009 - High-throughput Sequencing Workshop. Szeged, Hungary.

15-19.09.2008 - 4th European Vascular Genomics Network Summer School for PhD students in vascular biology. Cracow, Poland.

2-15.11.2007 - Analysis of microarray data - workshop. Nantes, France.

15-22.07.2006 - Summerschool – Methods for studying the role of oxidants and antioxidants in plants, food, man and animals. Institute of Human Nutrition and Food Science, Kiel University, Kiel, Germany. 

Professional Societies:

Member of Polish Society of Biochemistry 

Subject of interest:

·         Involvement of MCPIP1 in the regulation of NF-kappaB pathway.

·         Role of MCPIP1 in the development and progression of inflammatory diseases (atherosclerosis, psoriasis).

·         Inducible and constitutive in vivo gene deletion based on Cre/LoxP technology.

Most significant publications:

1. Grochot-Przeczek A, Kotlinowski J, Kozakowska M, Starowicz K, Jagodzinska J, Stachurska A, Volger OL, Bukowska-Strakova K, Florczyk U, Tertil M, Jazwa A, Szade K, Stepniewski J, Loboda A, Horrevoets AJ, Dulak J, Jozkowicz A. Heme oxygenase-1 is required for angiogenic function of bone marrow-derived progenitor cells: role in therapeutic revascularization. Antioxid Redox Signal. 2014 Apr 10;20(11):1677-92. doi: 10.1089/ars.2013.5426. Epub 2014 Feb 28. PubMed PMID: 24206054

2. Kotlinowski J, Dulak J, Józkowicz A. [Type 2 diabetes mellitus impairs endothelial progenitor cells functions]. Postepy Biochem. 2013;59(3):257-66. Review. Polish. PubMed PMID: 24364208

3. Miskinyte M, Sousa A, Ramiro RS, de Sousa JA, Kotlinowski J, Caramalho I, Magalhães S, Soares MP, Gordo I. The genetic basis of Escherichia coli pathoadaptation to macrophages. PLoS Pathog. 2013 Dec;9(12):e1003802. doi:10.1371/journal.ppat.1003802. Epub 2013 Dec 12. PubMed PMID: 24348252

4. Bartelik A, Ciesla M, Kotlinowski J, Bartelik S, Czaplicki D, Grochot-Przeczek A, Kurowski K, Koteja P, Dulak J, Józkowicz A. Development of hyperglycemia and diabetes in captive Polish bank voles. Gen Comp Endocrinol. 2013 Mar 1;183:69-78. doi: 10.1016/j.ygcen.2012.12.006. Epub 2013 Jan 3. PubMed PMID: 23291363

Publications from last 4 years:

1. Kotlinowski J, Jozkowicz A. PPAR Gamma and Angiogenesis: Endothelial Cells Perspective. J Diabetes Res. 2016;2016:8492353. doi: 10.1155/2016/8492353. Epub 2016 Dec 7. Review. PubMed PMID: 28053991

2. Losko M, Kotlinowski J, Jura J. Long Noncoding RNAs in Metabolic Syndrome Related Disorders. Mediators Inflamm. 2016;2016:5365209. Epub 2016 Nov 2. Review. PubMed PMID: 27881904

3. Kotlinowski J, Grochot-Przeczek A, Taha H, Kozakowska M, Pilecki B, Skrzypek K, Bartelik A, Derlacz R, Horrevoets AJ, Pap A, Nagy L, Dulak J, Jozkowicz A. PPARγ activation but not PPARγ haplodeficiency affects proangiogenic potential of endothelial cells and bone marrow-derived progenitors. Cardiovasc Diabetol. 2014 Nov 1;13:150. doi: 10.1186/s12933-014-0150-7. Erratum in: Cardiovasc Diabetol. 2015;14:65. PubMed PMID: 25361524

4. Kozakowska M, Kotlinowski J, Grochot-Przeczek A, Ciesla M, Pilecki B, Derlacz R, Dulak J, Jozkowicz A. Myoblast-conditioned media improve regeneration and revascularization of ischemic muscles in diabetic mice. Stem Cell Res Ther. 2015 Apr 12;6:61. doi: 10.1186/s13287-015-0063-8. PubMed PMID: 2588967625889676

5. Tertil M, Golda S, Skrzypek K, Florczyk U, Weglarczyk K, Kotlinowski J, Maleszewska M, Czauderna S, Pichon C, Kieda C, Jozkowicz A, Dulak J. Nrf2-heme oxygenase-1 axis in mucoepidermoid carcinoma of the lung: Antitumoral effects associated with down-regulation of matrix metalloproteinases. Free Radic Biol Med. 2015 Dec;89:147-57. doi: 10.1016/j.freeradbiomed.2015.08.004. Epub 2015 Sep 21. PubMed PMID: 26393425

6. Lipert B, Wegrzyn P, Sell H, Eckel J, Winiarski M, Budzynski A, Matlok M, Kotlinowski J, Ramage L, Malecki M, Wilk W, Mitus J, Jura J. Monocyte chemoattractant protein-induced protein 1 impairs adipogenesis in 3T3-L1 cells. Biochim Biophys Acta. 2014 Apr;1843(4):780-8. doi: 10.1016/j.bbamcr.2014.01.001. Epub 2014 Jan 10. PubMed PMID: 24418043

7. Kotlinowski J, Dulak J, Józkowicz A. [Type 2 diabetes mellitus impairs endothelial progenitor cells functions]. Postepy Biochem. 2013;59(3):257-66. Review. Polish. PubMed PMID: 24364208

8. Miskinyte M, Sousa A, Ramiro RS, de Sousa JA, Kotlinowski J, Caramalho I, Magalhães S, Soares MP, Gordo I. The genetic basis of Escherichia coli pathoadaptation to macrophages. PLoS Pathog. 2013 Dec;9(12):e1003802. doi: 10.1371/journal.ppat.1003802. Epub 2013 Dec 12. PubMed PMID: 24348252

9. Grochot-Przeczek A, Kotlinowski J, Kozakowska M, Starowicz K, Jagodzinska J, Stachurska A, Volger OL, Bukowska-Strakova K, Florczyk U, Tertil M, Jazwa A, Szade K, Stepniewski J, Loboda A, Horrevoets AJ, Dulak J, Jozkowicz A. Heme oxygenase-1 is required for angiogenic function of bone marrow-derived progenitor cells: role in therapeutic revascularization. Antioxid Redox Signal. 2014 Apr 10;20(11):1677-92. doi: 10.1089/ars.2013.5426. Epub 2014 Feb 28. PubMed PMID: 24206054

10. Florczyk U, Jazwa A, Maleszewska M, Mendel M, Szade K, Kozakowska M, Grochot-Przeczek A, Viscardi M, Czauderna S, Bukowska-Strakova K, Kotlinowski J, Jozkowicz A, Loboda A, Dulak J. Nrf2 regulates angiogenesis: effect on endothelial cells, bone marrow-derived proangiogenic cells and hind limb ischemia. Antioxid Redox Signal. 2014 Apr 10;20(11):1693-708. doi: 10.1089/ars.2013.5219. Epub 2013 Dec 18. PubMed PMID: 24053644

11. Kieda C, El Hafny-Rahbi B, Collet G, Lamerant-Fayel N, Grillon C, Guichard A, Dulak J, Jozkowicz A, Kotlinowski J, Fylaktakidou KC, Vidal A, Auzeloux P, Miot-Noirault E, Beloeil JC, Lehn JM, Nicolau C. Stable tumor vessel normalization with pO2 increase and endothelial PTEN activation by inositol trispyrophosphate brings novel tumor treatment. J Mol Med (Berl). 2013 Jul;91(7):883-99. doi: 10.1007/s00109-013-0992-6. Epub 2013 Mar 9. PubMed PMID: 23471434

12. Bartelik A, Ciesla M, Kotlinowski J, Bartelik S, Czaplicki D, Grochot-Przeczek A, Kurowski K, Koteja P, Dulak J, Józkowicz A. Development of hyperglycemia and diabetes in captive Polish bank voles. Gen Comp Endocrinol. 2013 Mar 1;183:69-78. doi: 10.1016/j.ygcen.2012.12.006. Epub 2013 Jan 3. PubMed PMID: 23291363